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 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 
 

Volume 1, Issue 1, January 2013


International Journal of Advance Research in Biology & Pharmacy Research (IJOARBP)
 
 

Bacterial Conjugation[ ]


The following note focuses on bacterial conjugation system specifically found in gram-negative bacteria that use type IV secretion system. Gram-negative bacteria uses type IV secretion system for a variety of biological functions including exchange of genetic material with other bacteria and translocation of oncogenic DNA and effector proteins into eukaryotic host cells. The type IV-secreted effectors play important roles in the virulence of some gram-negative pathogens.

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Metabolomics[ ]


A brief review on metabolomics, a new field being explored, which provides information regarding mechanisms of human health and diseases. Metabolomics deals with study of blood metabolites, circulating small molecules likes amino acids, lipids (fats), nucleotides, and carbohydrates involved in metabolism. Research on diseases like diabetes, kidney disease, and heart disease revealed dysfunction at molecular level before the actual clinical symptoms of the disease appear. Scientist have tried gene studying for knowledge of human body and diseases, but there are about 20,000 to 25,000 genes which encodes more than million proteins which further change into functionally modified proteins hence metabolomics comparatively has a decisive edge since there are only 3,000 to 6,000 metabolites of interest currently.

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Targeted Therapy[ ]


This is a review on targeted therapy that blocks the growth and spread of cancer by interfering with specific molecules involved in tumour growth and progression in comparison to chemotherapy, which targets the rapidly dividing cells. There are targeted therapies for breast cancer, multiple myeloma, lymphoma, prostate cancer, and other cancers. The drug targeted therapies interfere with a specific biochemical pathway responsible for growth, development, and spread of that particular cancer.

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Alzheimer Disease[ ]


A review about Alzheimer disease. Stages of Alzheimer's disease and researches carried out for determination of Alzheimer disease before the actual symptoms of disease occur, genetic predisposition, and treatment of Alzheimer disease.

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Munchausen's Syndrome[ ]


The paper is a review on Munchausen syndrome. Munchausen syndrome is a psychosomatic disorder where person fakes illness for attention and adoration from family, community, and friends. Person suffering with Munchausen syndrome can injure themselves and even people around them. It is a serious condition which involves careful monitoring of symptoms as it is difficult to predict and treatment often is difficult due to denial. Munchausen syndrome by proxy is a variant of MS which is now categorized as form of child abuse which involves parents or caregiver who abuse the child to fake symptoms for attention or monetary benefits.

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