Novel transition metal Zn(II) complexes of bidentate Schiff base ligands were obtained from 4-Methyl 7-hydroxy 8-formyl coumarin, and Dimethylamino propylene diamine and N-methylamino propylene diamine . Zn(II) complexes were also prepared by condensing with schiffs base of Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-ethyl-1,3-thiazole-5- carboxylate with Dimethylamino propylene diamine .
2-Butyl-5-amino-1-benzofuran, 4-(4-aminobenzyl)-1,3-oxazolidine-2-one and 4-(1H-1,2,4-triazol-1-yl methyl) aniline were synthesized by known litrature procedures and Schiff bases were prepared by condensation with salicyaldehyde and Zn(II) complexes were prepared subsequently by template method. All these Schiff bases and their Zn(II) metal complexes were characterized by physicochemicalal and spectral analytical methods. The synthesized Schiff bases act as bidentate ligand for the complexation reaction with Zn(II) ions. The new compounds, possess general formula [Zn(L)2.2H2O] and octahedral geometry is proposed. In order to evaluate the effect of metal ions upon chelation, the Schiff base and their metal complexes have been screened for antituberculosis activity against M.Tuberculosis. The transition metal complexes have shown moderate antimycobacterium activities as compared to standard Pyrazinamide and Streptomycin.