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 CURRENT ISSUES
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 Volume 1, Issue 1, Jan 2013
 
 

Volume 1, Issue 1, January 2013


International Journal of Advance Research in Applied Chemistry (IJOARAC)
 
 

Describing BCL- Family[ ]


The following note is a review on the Bcl-2 family protein encoded by gene BCLAF1. Bcl-2 proteins are apoptosis regulators that regulate mitochondrial outer membrane permeabilization (MOMP) and release cytochrome C (1-3) and can be pro-apoptotic or anti-apoptotic. There are totally 25 genes involved in Bcl-2 family. The BH family can be classified into 4 domains (BH1-4) which regulate protein interactions. Based upon function and sequence homology, BH family can be divided into pro-apoptotic which include Bcl-2, Mcl-1, Bcl-xL, A1 and Bcl-w. Pro-apoptotic proteins include Bax, Bak and Bok, and "BH3 only" proteins Bad, Bik, Bid, Puma, Bmf, Bim, Noxa and Hrk. The interactions between death promoting and death suppressing Bcl-2 family members has led to a rheostat model in which ration of pro-apoptotic and anti-apoptotic proteins control cell fate. The BH3-only members can bind and antagonize pro-survival members leading to increased apoptosis.

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A Review on Amino Acid Residues[ ]


The following review focuses on amino acid residues. Amino acid residues are formed by condensation of amino acids. Proteins, building blocks of body are broken down into amino acids on ingestion of proteinicious foods. Degradation of amino acids involves deamination through urea cycle to be excreted in the form of urea or in some cases uric acid or ammonia. After deamination the remainder of the molecule can be used in synthesis of new amino acids or used in the form of energy through glycolysis or the citric acid cycle.

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Molecular Aspects of Amylolytic Enymes[ ]


Enzymes acting on digestive system vary accordingly the substrate they are acting upon. Constituting a major portion of these enzymes are amylolytic enzymes acting on carbohydrates (starch and related oligosaccharides and monosaccharides). The following review focuses on structural features of amylolytic enzymes. Alpha amylase, beta amylase, and glucoamylase are the three most important amylolytic enzymes acting on carbohydrates, which have similar function of catalysis of hydrolysis of alpha-glycosidic bonds in starch and related saccharides but differ in mechanism of action, individually belong to different families, and adopt a different structure. Alpha amylase belongs to large clan of 3 families 13, 70, 77 and adopts a (beta/alpha) 8 barrel fold. Beta amylase belong to family 14 and also adopts (beta/alpha)8 barrel fold also know as TIM barrel fold. Glucoamylase belongs to family 15 and adopts a helical (alpha/alpha) 6 fold.

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Adsorption[ ]


A general review on adsorption. A process through which atoms, ions, and molecules from gas, liquid, or dissolved solid get adhered to the surface or bind to the surface. The process is weak and reversible. It is a surface-based process.

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Barking Dog Reaction[ ]


The following paper is a general review on barking dog reaction and much safer alternative to it.

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